A disrupted intestinal microbiome leads to epithelial rupture and inflammation. This increases the levels of SARS-CoV-2 target angiotensin-converting enzyme 2 (ACE2).
A disrupted intestinal microbiome is when the intestinal microbiota loses beneficial germs and becomes a breeding ground for potentially harmful germs.
“A specific intestinal microbiota combination can lead to severe COVID-19 infection in healthy individuals; proliferation of pro-inflammatory bacterial species associated with high levels of pro-inflammatory cytokines and disease severity. -Organ dysfunction, often accompanied by abnormal cytokine production, “says a 2021 review survey.
Therefore, a disrupted intestinal microbiome may also contribute to an increase in pro-inflammatory cytokine production (“cytokine storm”), which is known to worsen the severity of SARS-CoV-2 infection. ”